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What rhymes with neutron capture therapy of cancer?
neu·tron cap·ture ther·a·py of can·cer
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- Neutron capture therapy is a noninvasive therapeutic modality for treating locally invasive malignant tumors such as primary brain tumors and recurrent head and neck cancer. It is a two step procedure: first, the patient is injected with a tumor localizing drug containing a non-radioactive isotope that has a high propensity or cross section to capture slow neutrons. The cross section of the capture agent is many times greater than that of the other elements present in tissues such as hydrogen, oxygen and nitrogen. In the second step, the patient is radiated with epithermal neutrons, which after losing energy as they penetrate tissue, are absorbed by the capture agent which subsequently emits high-energy charged particles, thereby resulting in a biologically destructive nuclear reaction. All of the clinical experience to date with NCT is with the non-radioactive isotope boron-10, and this is known as boron neutron capture therapy. At this time, the use of other non-radioactive isotopes, such as gadolinium, has been limited, and to date, it has not been used clinically.
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