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salience net·work
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- The salience network (SN) is a large scale brain network of the human brain that is primarily composed of the anterior insula (AI) and dorsal anterior cingulate cortex (dACC). It is involved in detecting and filtering salient stimuli, as well as in recruiting relevant functional networks. Together with its interconnected brain networks, the SN contributes to a variety of complex functions, including communication, social behavior, and self-awareness through the integration of sensory, emotional, and cognitive information.The network is detectable through independent component analysis of resting state fMRI images, as well as seed based functional connectivity analysis. In addition to the AI and dACC, the salience network also consists of the substantia nigra, ventral tegmental area, ventral striatum, amygdala, dorsomedial thalamus, and hypothalamus. The functional connectivity has been linked with structural connectivity through diffusion tensor imaging, which reveals white matter tracts between the AI and dACC.
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