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shak·er (gene)

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The shaker (Sh) gene, when mutated, causes a variety of atypical behaviors in the fruit fly, Drosophila melanogaster. Under ether anesthesia, the fly’s legs will shake (hence the name); even when the fly is unanaesthetized, it will exhibit aberrant movements. Sh-mutant flies have a shorter lifespan than regular flies; in their larvae, the repetitive firing of action potentials as well as prolonged exposure to neurotransmitters at neuromuscular junctions occurs. In Drosophila, the shaker gene is located on the X chromosome. The closest human homolog is KCNA3.

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shake, shakedown, shaken, shakeout, shaker, shakers, shakes, shakespeare, shakespearean, shakeup

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