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wer·ner syn·drome

Werner syndrome is a rare, autosomal recessive progeroid syndrome, which is characterized by the appearance of premature aging. Werner syndrome is named after the German scientist Otto Werner. He identified the syndrome in four siblings observed with premature aging, which he explored as the subject of his dissertation of 1904. It has a global incidence rate of less than 1 in 100,000 per live birth; there have been 1,300 reported cases. Affected individuals typically grow and develop normally until puberty; the mean age of diagnosis is twenty-four, often realized when the adolescent growth spurt is not observed. The youngest person diagnosed was six years old. The median and mean age of death is 47-48 and 54 years, respectively; the main cause of death is cardiovascular disease or cancer.

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